What is the difference between Ketamine and Spravato® treatments?

While both ketamine and Spravato^® (esketamine) are used to treat depression, there are key differences in their formulation, administration, and FDA approval.

Spravato^® is a nasal spray that contains esketamine, a modified form of ketamine. It is FDA-approved specifically for treatment-resistant depression (TRD) and for adults with major depressive disorder (MDD) and acute suicidal ideation or behavior. Spravato^® must be administered in a certified medical setting under direct supervision, due to safety monitoring requirements.

Ketamine, by contrast, is most commonly administered via intravenous (IV) infusion and is used off-label for depression. While not FDA-approved specifically for mental health conditions, studies show that ketamine can offer rapid relief of depressive symptoms in some individuals.

Both treatments can be effective, but the right option depends on your symptoms, medical history, and treatment goals. At Being Health, our team will guide you through both options to determine what’s best for you.